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mannosyl-oligosaccharide 1,2-alpha-mannosidase 1C; HMIC; mannosidase alpha class 1C member 1; processing alpha-1,2-mannosidase 1C; alpha-1,2-mannosidase 1C (MAN1C1, MAN1A3, MAN1C)
Function:
1) protein modification; protein glycosylation
2) maturation of Asn-linked oligosaccharides (N-glycosylation)
3) trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce first Man(8)GlcNAc(2) then Man(6)GlcNAc & a small amount of Man(5)GlcNAc
4) hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
5) inhibited by both 1-deoxymannojirimycin & kifunensine
Cofactor: Ca+2
Structure: belongs to the glycosyl hydrolase 47 family
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein
Expression:
- expressed in most tissues except lung, muscle, pancreas
- highly expressed in placenta
Related
Asn glycosylation
General
Ca+2 binding protein
glycoprotein
glycosidase (glycoside hydrolase)
membrane protein
phosphoprotein
Properties
SIZE: entity length = 630 aa
MW = 71 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {23-43}
Ser phosphorylation site {S132}
N-glycosylation site {N250}
N-glycosylation site {N618}
Database Correlations
UniProt Q9NR34
Pfam PF01532
Entrez Gene 57134
Kegg hsa:57134
ENZYME 3.2.1.113
References
UniProt :accession Q9NR34