Search
mannosyl-oligosaccharide 1,2-alpha-mannosidase IB; mannosidase alpha class 1A member 2; Processing alpha-1,2-mannosidase IB; alpha-1,2-mannosidase IB (MAN1A2, MAN1B)
Function:
1) maturation of Asn-linked oligosaccharides, N-glycosylation
2) hydrolysis of the terminal 1,2-linked alpha-D- mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)
2) progressively trims alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2)
Cofactor: Ca+2
Inhibition:
- inhibited by 1-deoxymannojirimycin & kifunensine
Structure: belongs to the glycosyl hydrolase 47 family
Compartment:
- Golgi membrane
- single-pass type 2 membrane protein
Expression:
- highest levels of expression in placenta & testis
Related
Asn glycosylation
General
Ca+2 binding protein
glycoprotein
hydrolase
membrane protein
Properties
SIZE: entity length = 641 aa
MW = 73 kD
COMPARTMENT: golgi
MOTIF: transmembrane domain {37-57}
N-glycosylation site {N631}
Database Correlations
OMIM 604345
UniProt O60476
Pfam PF01532
Entrez Gene 10905
Kegg hsa:10905
ENZYME 3.2.1.113
References
UniProt :accession O60476