mannose-6-phosphate receptor-binding protein 1; cargo selection protein TIP47; 47 kD mannose 6-phosphate receptor-binding protein; 47 kD MPR-binding protein; placental protein 17 (PP17, M6PRBP1, TIP47, PLIN3)

Function: 1) transport of mannose 6-phosphate receptors from endosomes to trans-Golgi network 2) interacts with the cytoplasmic domains of both M6PR & IGF2R Structure: - homo-oligomer - isoform A also exists as a homodimer (known as PP17C) Compartment: - cytoplasm - endosome: membrane associated on endosomes - detected in envelope & core of lipid bodies & in lipid sails Alternative splicing: named isoforms=2

General

oligomerizing protein perilipin; lipid droplet-associated protein (PLIN) placental protein

Properties

SIZE: MW = 47 kD entity length = 434 aa COMPARTMENT: cellular compartment CELL: unspecified cell type WITHIN: placenta

Database Correlations

OMIM 602702 UniProt O60664 Pfam PF03036

References

UniProt :accession O60664