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malic enzyme 1 (NADP-ME, NADP-dependent malic enzyme, ME1)
Function:
- provides cytoplasmic malate from pyruvate
(S)-malate + NADP+ pyruvate + CO2 + NADPH
Cofactor: divalent metal cations, prefers Mg+2 or Mn+2
Structure:
- homotetramer
- belongs to the malic enzymes family
Compartment: cytoplasm
Expression:
- expressed in all tissues tested including liver, placenta & white adipose tissue
General
malic enzyme, malate decarboxylase or malate oxidoreductase
oligomerizing protein
Properties
SIZE: entity length = 572 aa
MW = 64 kD
COMPARTMENT: cytoplasm
MOTIF: tyrosine residue {Y102}
cofactor-binding site [155-155]
COFACTOR-BOUND: NADP
lysine residue {K173}
cofactor-binding site [269-269]
COFACTOR-BOUND: NADP
MOTIF: regulatory site {269-269}
cofactor-binding site [301-318]
COFACTOR-BOUND: NADP
cofactor-binding site [408-408]
COFACTOR-BOUND: NADP
Database Correlations
OMIM 154250
UniProt P48163
PFAM correlations
KEGG correlations
ENZYME 1.1.1.40
References
- UniProt :accession P48163
- HMPD; The Singapore human mutation & polymorphism database
http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=ME1