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malate dehydrogenase-2 (mitochondrial malate dehydrogenase, MDH2)
Function:
- catalyzes conversion of malate to oxaloacetate
(S)-malate + NAD+ oxaloacetate + NADH
Structure:
- homodimer
- belongs to the LDH/MDH superfamily, MDH type 1 family
Compartment: mitochondrial matrix
General
citric acid cycle enzyme
malate dehydrogenase
Properties
SIZE: entity length = 338 aa
MW = 36 kD
COMPARTMENT: mitochondrial matrix
MOTIF: cofactor-binding site [31-37]
COFACTOR-BOUND: NAD
Tyr phosphorylation site {Y56}
cofactor-binding site [57-57]
COFACTOR-BOUND: NAD
binding site
SITE: 104-104
FOR-BINDING-OF: Substrate
binding site
SITE: 110-110
FOR-BINDING-OF: Substrate
cofactor-binding site [117-117]
COFACTOR-BOUND: NAD
cofactor-binding site [140-142]
COFACTOR-BOUND: NAD
MOTIF: binding site
SITE: 142-142
FOR-BINDING-OF: Substrate
binding site
SITE: 176-176
FOR-BINDING-OF: Substrate
histidine residue {H200}
cofactor-binding site [251-251]
COFACTOR-BOUND: NAD
Database Correlations
OMIM 154100
UniProt P40926
PFAM correlations
ENZYME 1.1.1.37
References
- UniProt :accession P40926
- Wikipedia; note=malate dehydrogenase entry
http://en.wikipedia.org/wiki/malate_dehydrogenase