protein MAL2 (MAL2)

Function: - member of the machinery of polarized transport - required for the indirect transcytotic route at the step of the egress of the transcytosing cargo from perinuclear endosomes in order for it to travel to the apical surface via a raft-dependent pathway - interacts with TPD52L2 Structure: - belongs to the MAL family - contains 1 MARVEL domain Compartment: - cell membrane; multi-pass membrane protein - apical cell membrane; multi-pass membrane protein. - endomembrane system - cytoplasm, perinuclear region - associated with lipid rafts - in polarized epithelial cells, restricted to the apical surface - in hepatocytes, as well as in polarized hepatoma hepG2 cells, found in the canalicular membrane, equivalent to the apical surface, beneath the canalicular actin cytoskeleton - in non-polarized hepG2 cells, distributed to the perinuclear region Expression: - predominantly expressed in kidney, lung, & liver - also found in thyroid gland, stomach &, at lower levels in testis & small intestine

General

glycoprotein membrane protein

Properties

SIZE: entity length = 176 aa MW = 19 kD COMPARTMENT: cytoplasm cell nucleus MOTIF: cytoplasmic domain {1-34} MARVEL {31-175} MOTIF: transmembrane domain {35-55} exoplasmic loop {56-66} transmembrane domain {67-87} cytoplasmic loop {88-102} transmembrane domain {103-123} exoplasmic loop {124-149} N-glycosylation site {N132} transmembrane domain {150-170} cytoplasmic domain {171-176}

Database Correlations

OMIM 609684 UniProt Q969L2 Pfam PF01284 Entrez Gene 114569 Kegg hsa:114569

References

UniProt :accession Q969L2