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bone marrow proteoglycan; BMPG; proteoglycan 2; contains: eosinophil granule major basic protein; EMBP; MBP; pregnancy-associated major basic protein (PRG2, MBP)
Function:
- cytotoxin & helminth toxin
- also induces non-cytolytic histamine release from basophils
- role in parasitic infection defense mechanisms & in immune hypersensitivity reactions
- proform acts as a proteinase inhibitor, reducing activity of PAPPA
- nitrated
- in pregnancy serum, the proform exists as a disulfide-linked 2:2 heterotetramer with PAPPA, as a disulfide-linked 2:2 heterotetramer with AGT, & as a complex (probably a 2:2:2 heterohexamer) with AGT & C3dg
- binds heparin
- does not bind Ca+2
Structure:
- contains 1 C-type lectin domain
Compartment:
- bone marrow proteoglycan: secreted
- the proform is secreted
- eosinophil granule major basic protein:
- cytoplasmic vesicle, secretory vesicle
- mature protein is found in the matrix of the eosinophil's large specific granule (crystalloid core)
Expression:
- high levels of the proform in placenta & pregnancy serum
- in placenta, localized to X cells of septa & anchoring villi
- lower levels in a variety of other tissues including kidney, myometrium, endometrium, ovaries, breast, prostate, bone marrow & colon
- levels of the proform increase in serum & placenta during pregnancy
Related
eosinophil major basic protein Ag in tissue
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 222 aa
MW = 25 kD
COMPARTMENT: cytoplasm
MOTIF: signal sequence {1-16}
Thr glycosylation site {T23}
Ser glycosylation site {S24}
Thr glycosylation site {T25}
Thr glycosylation site {T34}
cysteine residue {C51}
MODIFICATION: cysteine residue {C461 IN PAPPA}
Ser glycosylation site {S62}
N-glycosylation site {N86}
C-type lectin {104-222}
MOTIF: cysteine residue {C125}
MODIFICATION: cysteine residue {C220}
cysteine residue {C169}
MODIFICATION: cysteine residue {C732 IN PAPPA}
cysteine residue {C197}
MODIFICATION: cysteine residue {C212}
cysteine residue {C212}
MODIFICATION: cysteine residue {C197}
cysteine residue {C220}
MODIFICATION: cysteine residue {C125}
Database Correlations
OMIM 605601
UniProt P13727
Pfam PF00059
Entrez Gene 5553
Kegg hsa:5553
References
- UniProt :accession P13727
- Wikipedia; Note: major basic protein entry
http://en.wikipedia.org/wiki/major_basic_protein
- Functional glycomics gateway - glycan binding
Note: Eosinophil major basic protein
http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_207