Mad/max complex

Function: - Myc-max & Mad-max have similar DNA binding specifities - transcription repression may require binding of Mad to mSin3A/B

Properties

SUBUNITS: MAD protein MOTIF: nuclear translocation signal {21-49} basic helix-loop-helix {58-108} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix EFFECTOR-BOUND: protein max COMPARTMENT: cell nucleus MOTIF: Ser phosphorylation site {S2} Ser phosphorylation site {S11} DNA-binding motif SITE: 24-36 helix-loop-helix NAME: helix-loop-helix SITE: 39-75 FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 81-102 FOR-BINDING-VIA: leucine zipper Tyr phosphorylation site {Y123} nuclear translocation signal {152-156} FOR-BINDING-OF: DNA motif BOUND-VIA: basic helix-loop-helix {BHLH} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix helix-loop-helix NAME: helix-loop-helix SITE: 70-109 FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 101-143 EFFECTOR-BOUND: protein max BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper protein max CONFIGURATION: monomer MOTIF: Ser phosphorylation site {S2} Ser phosphorylation site {S11} DNA-binding motif SITE: 24-36 helix-loop-helix NAME: helix-loop-helix SITE: 39-75 FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 81-102 FOR-BINDING-VIA: leucine zipper basic helix-loop-helix {BHLH} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix EFFECTOR-BOUND: MAD protein COMPARTMENT: cell nucleus MOTIF: nuclear translocation signal {21-49} DNA-binding motif SITE: 58-69 helix-loop-helix NAME: helix-loop-helix SITE: 70-109 FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: 101-143 FOR-BINDING-VIA: leucine zipper FOR-BINDING-OF: DNA motif BOUND-VIA: basic helix-loop-helix {58-108} MOTIF: basic DNA-binding motif helix-loop-helix NAME: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-OF: DNA motif FOR-BINDING-VIA: helix-loop-helix FOR-BINDING-VIA: helix-loop-helix leucine zipper SITE: LZ EFFECTOR-BOUND: MAD protein BOUND-VIA: leucine zipper FOR-BINDING-VIA: leucine zipper Tyr phosphorylation site {Y123} nuclear translocation signal {152-156} MISC-INFO: RECOGNITION-MOTIF :SEQUENCE CACGTG

References

Ayer et al. Cell 767-776 1995

Components

MAD protein; MAX dimerizer; MAX dimerization protein 1 (MXD1, MAD) protein max; Myc-associated factor X (MAX)