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hepatocyte growth factor-like protein; macrophage stimulatory protein; macrophage-stimulating protein; MSP; contains: hepatocyte growth factor-like protein alpha chain; hepatocyte growth factor-like protein beta chain (MST1, D3F15S2, DNF15S2, HGFL)
Function:
- probably has no proteolytic activity, since crucial characteristicS of serine proteases catalytic sites are not conserved
- may be cleaved after Arg-483, to yield two chains held together by disulfide bonds, or two separate polypeptides
- dimer of an alpha chain & a beta chain linked by a disulfide bond
Structure:
- belongs to the peptidase S1 family, plasminogen subfamily
- contains 4 kringle domains
- contains 1 PAN domain
- contains 1 peptidase S1 domain
Compartment: secreted
General
glycoprotein
secreted protein
Properties
SIZE: entity length = 711 aa
MW = 80 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
PAN {21-105}
MOTIF: cysteine residue {C56}
MODIFICATION: cysteine residue {C78}
cysteine residue {C60}
MODIFICATION: cysteine residue {C66}
cysteine residue {C66}
MODIFICATION: cysteine residue {C60}
N-glycosylation site {N72}
cysteine residue {C78}
MODIFICATION: cysteine residue {C56}
Kringle {110-448} (4)
MOTIF: cysteine residue {C110}
MODIFICATION: cysteine residue {C186}
cysteine residue {C131}
MODIFICATION: cysteine residue {C169}
cysteine residue {C157}
MODIFICATION: cysteine residue {C181}
cysteine residue {C169}
MODIFICATION: cysteine residue {C131}
cysteine residue {C181}
MODIFICATION: cysteine residue {C157}
cysteine residue {C186}
MODIFICATION: cysteine residue {C110}
cysteine residue {C468}
MODIFICATION: cysteine residue {C-INTERCHAIN}
S1 domain {484-709}
MOTIF: cysteine residue {C507}
MODIFICATION: cysteine residue {C523}
cysteine residue {C523}
MODIFICATION: cysteine residue {C507}
cysteine residue {C602}
MODIFICATION: cysteine residue {C667}
N-glycosylation site {N615}
cysteine residue {C632}
MODIFICATION: cysteine residue {C646}
cysteine residue {C646}
MODIFICATION: cysteine residue {C632}
cysteine residue {C657}
MODIFICATION: cysteine residue {C685}
cysteine residue {C667}
MODIFICATION: cysteine residue {C602}
cysteine residue {C685}
MODIFICATION: cysteine residue {C657}
Database Correlations
OMIM 142408
UniProt P26927
PFAM correlations
Entrez Gene 4485
Kegg hsa:4485
References
UniProt :accession P26927