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macrophage-stimulating protein receptor; MSP receptor; p185-Ron; CDw136; CD136 (MST1R, PTK8, RON)
Function:
- receptor for macrophage stimulating protein (MSP)
- has a tyrosine-protein kinase activity
- binds PLXNB1
- associates with & is negatively regulated by HYAL2
- proteolytic processing yields the two subunits
- phosphorylated in response to ligand binding (probable)
Structure:
- heterodimer formed of an alpha chain & a beta chain which are disulfide linked
- belongs to the protein kinase superfamily, Tyr protein kinase family
- contains 3 IPT/TIG domains
- contains 1 protein kinase domain
- contains 1 Sema domain
Compartment: membrane
Alternative splicing: named isoforms=2
delta-RON lacks part of the extracellular domain, oligomerizes & is constitutively activated
Expression: keratinocytes & lung
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
tyrosine kinase receptor (RTK)
Properties
SIZE: entity length = 1400 aa
MW = 152 kD
COMPARTMENT: cellular membrane
STATE: active state
MOTIF: signal sequence {1-24}
Sema {31-522}
MOTIF: N-glycosylation site {N66}
arginine-rich region {306-309}
MOTIF: arginine residue (SEVERAL)
N-glycosylation site {N419}
N-glycosylation site {N458}
N-glycosylation site {N488}
IPT/TIG 1 {569-671}
MOTIF: N-glycosylation site {N654}
IPT/TIG 2 {684-767}
MOTIF: N-glycosylation site {N720}
IPT/TIG 3 {770-860}
MOTIF: N-glycosylation site {N841}
N-glycosylation site {N897}
transmembrane domain {958-978}
kinase domain
SITE: 1082-1345
MOTIF: ATP-binding site
NAME: ATP-binding site
SITE: 1088-1096
ATP-binding site
NAME: ATP-binding site
SITE: 1114-1114
aspartate residue {D1208}
Tyr phosphorylation site {Y1353}
Tyr phosphorylation site {Y1360}
Database Correlations
OMIM 600168
UniProt Q04912
PFAM correlations
Kegg hsa:4486
ENZYME 2.7.10.1
References
- UniProt :accession Q04912
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/RONID287.html