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macrophage scavenger receptor types 1 & 2; macrophage acetylated LDL receptor 1 & 2; scavenger receptor class A member 1 (CD204, MSR1, SCARA1)
Function:
- endocytosis of a diverse group of macromolecules, including modified low density lipoproteins (LDL)
- binding of acetylated & oxidized cholesterol
- may also bind aggregates of LDL:heparin:fibronectin
Structure:
- homotrimer
- contains 1 collagen-like domain
- contains 1 SRCR domain
Compartment: membrane
Alternative splicing: named isoforms=2 May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay
Pathology:
- implicated in the pathologic deposition of cholesterol in arterial walls during atherogenesis
Related
fibronectin; FN; cold-insoluble globulin; CIG; contains: anastellin; Ugl-Y1; Ugl-Y2; Ugl-Y3 (FN1, FN)
heparin
high density lipoprotein (HDL)
low density lipoprotein (LDL, beta-lipoprotein)
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
oligomerizing protein
scavenger receptor
Properties
CONFIGURATION: trimer
SIZE: MW = 50 kD
entity length = 451 aa
COMPARTMENT: plasma membrane
CELL: macrophage
kupffer cell
WITHIN: liver
MOTIF: transmembrane domain {51-76}
SPACER {77-109}
MOTIF: N-glycosylation site {N82}
N-glycosylation site {N102}
N-glycosylation site {N143}
coiled coil {171-255}
MOTIF: N-glycosylation site {N184}
N-glycosylation site {N221}
N-glycosylation site {N249}
N-glycosylation site {N267}
COLLAGEN-LIKE {273-341}
SRCR {350-450}
MOTIF: cysteine residue {C375}
MODIFICATION: cysteine residue {C439}
cysteine residue {C388}
MODIFICATION: cysteine residue {C449}
cysteine residue {C419}
MODIFICATION: cysteine residue {C429}
cysteine residue {C429}
MODIFICATION: cysteine residue {C419}
cysteine residue {C439}
MODIFICATION: cysteine residue {C375}
cysteine residue {C449}
MODIFICATION: cysteine residue {C388}
Database Correlations
OMIM 153622
MORBIDMAP 153622
UniProt P21757
PFAM correlations
Kegg hsa:4481
References
UniProt :accession P21757