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macrophage mannose receptor 2 (urokinase receptor-associated protein, endocytic receptor 180, CD280 antigen, MRC2, ENDO180, KIAA0709, UPARAP)
Function:
1) endocytotic lectin receptor (Ca+2-dependent)
2) internalizes glycosylated ligands via clathrin-mediated endocytosis
3) role in plasminogen activation, regulating extracellular PLAUR/PLAU, & thus regulation of protease activity at the cell surface (putative)
4) uptake & degradation of extracellular collagen matrices co-operating with matrix metalloproteinases (putative)
5) interacts with COL1A1, PLAUR, PLAU, collagen-5
6) phosphorylated
Structure:
- N-glycosylated
- contains 8 C-type lectin domains
a) C-type lectin domains 3 to 8 are not required for Ca+2-dependent binding of mannose, fucose & N-acetylglucosamine
b) C-type lectin domain 2 is responsible for sugar-binding (Ca+2-dependent)
- contains 1 fibronectin type-II domain
- fibronectin type-II domain mediates collagen-binding
- contains 1 ricin B-type lectin domain
- ricin B-type lectin domain contacts with the 2nd C-type lectin domain (putative)
Compartment: membrane
Expression:
- ubiquitous
- low expression in brain, placenta, lung, kidney, pancreas, spleen, thymus & colon
- expressed in endothelial cells, fibroblasts & macrophages
- highly expressed in fetal lung & kidney
Pathology:
- may play role in cancer progression & other chronic tissue destructive diseases acting on collagen turnover
Related
macrophage
macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; CD206 (MRC1, CLEC13D)
mannose
General
Ca+2 binding protein
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
cell surface receptor
lectin
Properties
SIZE: MW = 167 kD
entity length = 1479 aa
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-30}
RICIN B-TYPE LECTIN {41-167}
MOTIF: cysteine residue {C54}
MODIFICATION: cysteine residue {C68}
cysteine residue {C68}
MODIFICATION: cysteine residue {C54}
N-glycosylation site {N69}
cysteine residue {C93}
MODIFICATION: cysteine residue {C112}
cysteine residue {C112}
MODIFICATION: cysteine residue {C93}
N-glycosylation site {N140}
fibronectin type II domain or F2 module
SITE: 182-230
FOR-BINDING-OF: collagen
MOTIF: cysteine residue {*1}
MODIFICATION: cysteine residue {*3}
cysteine residue {*2}
MODIFICATION: cysteine residue {*4}
cysteine residue {*3}
MODIFICATION: cysteine residue {*1}
cysteine residue {*4}
MODIFICATION: cysteine residue {*2}
cysteine residue {C187}
MODIFICATION: cysteine residue {C213}
cysteine residue {C201}
MODIFICATION: cysteine residue {C228}
cysteine residue {C213}
MODIFICATION: cysteine residue {C187}
cysteine residue {C228}
MODIFICATION: cysteine residue {C201}
C-TYPE LECTIN {244-1393} (8)
MOTIF: cysteine residue {C266}
MODIFICATION: cysteine residue {C359}
cysteine residue {C335}
MODIFICATION: cysteine residue {C351}
cysteine residue {C351}
MODIFICATION: cysteine residue {C335}
cysteine residue {C359}
MODIFICATION: cysteine residue {C266}
N-glycosylation site {N954}
transmembrane domain {1415-1435}
Database Correlations
UniProt Q9UBG0
PFAM correlations
References
UniProt :accession Q9UBG0