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macrophage mannose receptor 1; MMR; C-type lectin domain family 13 member D; CD206 (MRC1, CLEC13D)

Function: - mediates the endocytosis of glycoproteins by macrophages - binds both sulfated & non-sulfated polysaccharide chains - acts as phagocytic receptor for bacteria, fungi & other pathogens Structure: - contains 8 C-type lectin domains a) domains 1-3 have at most very weak affinity for carbohydrate b) domain 4 shows the highest affinity binding & has multispecificity for a variety of monosaccharides c) at least 3 domains (4, 5, & 7) are required for high affinity binding & endocytosis of multivalent glycoconjugates - contains 1 fibronectin type-II domain - contains 1 ricin B-type lectin domain Compartment: membrane

Related

macrophage macrophage mannose receptor 2 (urokinase receptor-associated protein, endocytic receptor 180, CD280 antigen, MRC2, ENDO180, KIAA0709, UPARAP) mannose

General

Ca+2 binding protein cluster-of-differentiation antigen; cluster designation antigen; CD antigen cell surface receptor glycoprotein lectin

Properties

SIZE: entity length = 1456 aa MW = 166 kD COMPARTMENT: cellular membrane MOTIF: signal sequence {1-18} Ricin B-type lectin {22-142} MOTIF: cysteine residue {C35} MODIFICATION: cysteine residue {C49} cysteine residue {C49} MODIFICATION: cysteine residue {C35} cysteine residue {C74} MODIFICATION: cysteine residue {C91} cysteine residue {C91} MODIFICATION: cysteine residue {C74} N-glycosylation site {N104} fibronectin type II domain or F2 module SITE: 163-211 FOR-BINDING-OF: collagen MOTIF: cysteine residue {*1} MODIFICATION: cysteine residue {*3} cysteine residue {*2} MODIFICATION: cysteine residue {*4} cysteine residue {*3} MODIFICATION: cysteine residue {*1} cysteine residue {*4} MODIFICATION: cysteine residue {*2} cysteine residue {C168} MODIFICATION: cysteine residue {C194} cysteine residue {C182} MODIFICATION: cysteine residue {C209} cysteine residue {C194} MODIFICATION: cysteine residue {C168} cysteine residue {C209} MODIFICATION: cysteine residue {C182} C-type lectin 1 {225-341} MOTIF: cysteine residue {C247} MODIFICATION: cysteine residue {C340} cysteine residue {C316} MODIFICATION: cysteine residue {C332} cysteine residue {C332} MODIFICATION: cysteine residue {C316} cysteine residue {C340} MODIFICATION: cysteine residue {C247} N-glycosylation site {N344} C-type lectin 2 {369-487} MOTIF: cysteine residue {C391} MODIFICATION: cysteine residue {C486} cysteine residue {C463} MODIFICATION: cysteine residue {C478} cysteine residue {C478} MODIFICATION: cysteine residue {C463} cysteine residue {C486} MODIFICATION: cysteine residue {C391} C-type lectin 3 {511-626} MOTIF: N-glycosylation site {N529} cysteine residue {C532} MODIFICATION: cysteine residue {C625} cysteine residue {C600} MODIFICATION: cysteine residue {C617} cysteine residue {C617} MODIFICATION: cysteine residue {C600} cysteine residue {C625} MODIFICATION: cysteine residue {C532} cysteine residue {C646} MODIFICATION: cysteine residue {C659} C-type lectin 4 {655-778} MOTIF: cysteine residue {C659} MODIFICATION: cysteine residue {C646} cysteine residue {C680} MODIFICATION: cysteine residue {C777} cysteine residue {C753} MODIFICATION: cysteine residue {C769} cysteine residue {C769} MODIFICATION: cysteine residue {C753} cysteine residue {C777} MODIFICATION: cysteine residue {C680} C-type lectin 5 {807-923} MOTIF: cysteine residue {C828} MODIFICATION: cysteine residue {C922} cysteine residue {C899} MODIFICATION: cysteine residue {C914} cysteine residue {C914} MODIFICATION: cysteine residue {C899} cysteine residue {C922} MODIFICATION: cysteine residue {C828} N-glycosylation site {N926} N-glycosylation site {N930} C-type lectin 6 {952-1080} MOTIF: cysteine residue {C977} MODIFICATION: cysteine residue {C1079} cysteine residue {C1052} MODIFICATION: cysteine residue {C1071} cysteine residue {C1071} MODIFICATION: cysteine residue {C1052} cysteine residue {C1079} MODIFICATION: cysteine residue {C977} C-type lectin 7 {1102-1213} MOTIF: cysteine residue {C1123} MODIFICATION: cysteine residue {C1212} N-glycosylation site {N1160} cysteine residue {C1190} MODIFICATION: cysteine residue {C1204} cysteine residue {C1204} MODIFICATION: cysteine residue {C1190} N-glycosylation site {N1205} cysteine residue {C1212} MODIFICATION: cysteine residue {C1123} C-type lectin 8 {1241-1356} MOTIF: cysteine residue {C1263} MODIFICATION: cysteine residue {C1355} N-glycosylation site {N1311} cysteine residue {C1332} MODIFICATION: cysteine residue {C1347} cysteine residue {C1347} MODIFICATION: cysteine residue {C1332} cysteine residue {C1355} MODIFICATION: cysteine residue {C1263} transmembrane domain {1390-1410}

Database Correlations

OMIM 153618 UniProt P22897 PFAM correlations Entrez Gene 4360 Kegg hsa:4360

References

  1. UniProt :accession P22897
  2. Functional Glycomics gateway - Glycan binding: macrophage mannose receptor http://www.functionalglycomics.org/glycomics/GBPServlet?&operationtype=view&cbpId=cbp_hum_Ctlect_00127