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C-C motif chemokine 19; beta-chemokine exodus-3; CK beta-11; Epstein-Barr virus-induced molecule 1 ligand chemokine; EBI1 ligand chemokine; ELC; macrophage inflammatory protein 3 beta; MIP-3-beta; small-inducible cytokine A19 (CCL19, ELC, MIP3B, SCYA19)
Function:
- may play a role not only in inflammatory & immunological responses but also in normal lymphocyte recirculation & homing
- may play a role in trafficking of T-cells in thymus, & T-cell & B-cell migration to secondary lymphoid organs
- specifically binds to chemokine receptor CCR7
- recombinant CCL19
- potent chemotactic activity for T-cells & B-cells
- not chemotactic for granulocytes or monocytes
Structure:
- belongs to the intercrine beta (chemokine CC) family
Compartment: secreted
Expression:
- expressed lymph nodes, thymus & appendix > colon & trachea > spleen, small intestine, lung, kidney & stomach
Interactions
molecular events
General
CC chemokine; beta chemokine
Properties
SIZE: entity length = 98 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
cysteine residue {C29}
MODIFICATION: cysteine residue {C55}
cysteine residue {C30}
MODIFICATION: cysteine residue {C71}
cysteine residue {C55}
MODIFICATION: cysteine residue {C29}
cysteine residue {C71}
MODIFICATION: cysteine residue {C30}
References
- UniProt :accession Q99731
- Wikipedia; Note: CCL19 entry
http://en.wikipedia.org/wiki/CCL19
Component-of
molecular complex
Databases & Figures
OMIM 602227
UniProt Q99731
Pfam PF00048
Entrez Gene 6363
Kegg hsa:6363
CC ligand and receptor binding