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C-C motif chemokine 20; beta-chemokine exodus-1; CC chemokine LARC; liver & activation-regulated chemokine; macrophage inflammatory protein 3 alpha; MIP-3-alpha; small-inducible cytokine A20 (CCL20, LARC, MIP3A, SCYA20)
Function:
- chemotactic factor that attracts lymphocytes &, to lesser extent, neutrophils
- not chemotactic for monocytes
- inhibits proliferation of myeloid progenitors in colony formation assays
- may be involved in formation & function of mucosal lymphoid tissues by attracting lymphocytes & dendritic cells towards epithelial cells
- C-terminal processed forms have equal chemotactic activity for leukocytes
- antibacterial activity E coli ATCC 25922 & S aureus ATCC 29213
- C-terminal processed forms which lack 1, 3 or 6 amino acids are produced by proteolytic cleavage after secretion from peripheral blood monocytes
- binds to & activates CCR6
Structure:
- belongs to the intercrine beta (chemokine CC) family
Compartment: secreted
Alternative splicing: named isoforms=2
Expression:
- expressed predominantly in the liver, lymph nodes, appendix, peripheral blood lymphocytes, & fetal lung
- low expression in thymus, prostate, testis, small intestine & colon
- induced by bacterial lipopolysaccharides (LPS), TNF zzzzzzzzzzzzz7 IFN-gamma
- induced by phorbol myristate acetate (PMA) in U937 cell line & Bowes melanoma
- repressed by IL-10
Interactions
molecular events
General
CC chemokine; beta chemokine
Properties
SIZE: entity length = 96 aa
MW = 11 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-26}
cysteine residue {C32}
MODIFICATION: cysteine residue {C58}
cysteine residue {C33}
MODIFICATION: cysteine residue {C74}
cysteine residue {C58}
MODIFICATION: cysteine residue {C32}
cysteine residue {C74}
MODIFICATION: cysteine residue {C33}
References
- UniProt :accession P78556
- Wikipedia; Note: CCL20 entry
http://en.wikipedia.org/wiki/CCL20
Component-of
molecular complex
Databases & Figures
OMIM 601960
UniProt P78556
Pfam PF00048
Entrez Gene 6364
Kegg hsa:6364
CC ligand and receptor binding