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C-C motif chemokine 4; G-26 T-lymphocyte-secreted protein; HC21; lymphocyte activation gene 1 protein; LAG-1; MIP-1-beta(1-69); macrophage inflammatory protein 1-beta; MIP-1-beta; PAT 744; protein H400; SIS-gamma; small-inducible cytokine A4; T-cell activation protein 2; ACT-2; contains: MIP-1-beta(3-69) (CCL4, LAG1, MIP1B, SCYA4)

Function: - monokine with inflammatory & chemokinetic properties - binds to CCR5 - one of the major HIV-suppressive factors produced by CD8+ T-cells - recombinant MIP-1-beta induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV) - the processed form MIP-1-beta(3-69) retains ability to induce down-regulation of surface expression of the chemokine receptor CCR5 & to inhibit the CCR5-mediated entry of HIV-1 in T-cells - N-terminal processed form MIP-1-beta(3-69) is produced by proteolytic cleavage after secretion from peripheral blood lymphocytes - MIP-1-beta(3-69) is also a ligand for CCR1 & CCR2 isoform B - homodimer & heterodimer of MIP-1-alpha(4-69) & MIP-1-beta(3-69) Structure: - belongs to the intercrine beta (chemokine CC) family Compartment: secreted Expression: induced by mitogens Note: - originally thought to be a ligand for CCR8 [1]

Interactions

molecular events

Related

C-C motif chemokine 4-like; small-inducible cytokine A4-like; lymphocyte activation gene 1 protein; LAG-1; macrophage inflammatory protein 1-beta; monocyte adherence-induced protein 5-alpha (CCL4L1, CCL4L, LAG1, SCYA4L1, CCL4L2, SCYA4L2)

General

CC chemokine; beta chemokine monokine sis family protein

Properties

SIZE: entity length = 92 aa MW = 10 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-23} cysteine residue {C34} MODIFICATION: cysteine residue {C58} cysteine residue {C35} MODIFICATION: cysteine residue {C74} cysteine residue {C58} MODIFICATION: cysteine residue {C34} cysteine residue {C74} MODIFICATION: cysteine residue {C35} SECRETED-BY: monocyte fibroblast T-cell

Database Correlations

OMIM 182284 UniProt P13236 Pfam PF00048 LOCUS-LINK correlations KEGG correlations

References

  1. UniProt :accession P13236
  2. Wikipedia; Note: macrophage inflammatory protein entry http://en.wikipedia.org/wiki/macrophage_inflammatory_protein
  3. Henderson B & Blake S Therapeutic potential of cytokine manipulation TIPS 13:145 1992 PMID: 1589908
  4. Hopkins SJ & Rothwell NJ Cytokines and the nervous system. I: Expression and recognition. TINS 18:83 1995 PMID: 7537419