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C-C motif chemokine 3; G0/G1 switch regulatory protein 19-1; macrophage inflammatory protein 1-alpha; MIP-1-alpha; PAT 464.1; SIS-alpha; small-inducible cytokine A3; tonsillar lymphocyte LD78 alpha protein; contains: MIP-1-alpha(4-69); LD78-alpha(4-69) (CCL3, G0S19-1, MIP1A, SCYA3)
Function:
- monokine with inflammatory & chemokinetic properties
- binds to CCR1, CCR4 & CCR5
- one of the major HIV-suppressive factors produced by CD8+ T-cells
- recombinant MIP-1-alpha induces a dose-dependent inhibition of different strains of HIV-1, HIV-2, & simian immunodeficiency virus (SIV)
- N-terminal processed form LD78-alpha(4-69) is produced by proteolytic cleavage after secretion from HTLV1-transformed T-cells
- self-associates
- also heterodimer of MIP-1-alpha(4-69) & MIP-1-beta(3-69)
Structure:
- belongs to the intercrine beta (chemokine CC) family
Compartment: secreted
Expression:
- induced by phorbol esters TPA, PMA & phytohemagglutinin (T-cell mitogen)
Interactions
molecular events
General
CC chemokine; beta chemokine
monokine
sis family protein
Properties
SIZE: entity length = 92 aa
MW = 10 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-23}
cysteine residue {C33}
MODIFICATION: cysteine residue {C57}
cysteine residue {C34}
MODIFICATION: cysteine residue {C73}
arginine residue {40}
cysteine residue {C57}
MODIFICATION: cysteine residue {C33}
arginine residue {68}
arginine residue {70}
cysteine residue {C73}
MODIFICATION: cysteine residue {C34}
SECRETED-BY: monocyte
fibroblast
T-cell
Database Correlations
OMIM 182283
UniProt P10147
Pfam PF00048
Entrez Gene 6348
Kegg hsa:6348
References
- UniProt :accession P10147
- Wikipedia; Note: macrophage inflammatory protein entry
http://en.wikipedia.org/wiki/macrophage_inflammatory_protein
- Henderson B & Blake S
Therapeutic potential of cytokine manipulation
TIPS 13:145 1992
PMID: 1589908
- Entrez Gene :accession 6348