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macrophage erythroblast attacher (erythroblast macrophage protein, proliferation-inducing protein 5, lung cancer-related protein 10, MAEA, EMP)
Function:
1) role in erythroblast enucleation & in development of mature macrophages
2) mediates attachment of erythroid cell to mature macrophages, in correlation with the presence of MAEA at cell surface of mature macrophages
3) MAEA-mediated contact inhibits erythroid cells apoptosis
4) role in erythroblastic island formation, functional unit of erythropoiesis
5) associates with F-actin to regulate actin distribution in erythroblasts & macrophages
6) role in nuclear architecture & cell division events (putative)
Structure:
- contains 1 CTLH domain
- contains 1 LisH domain
Compartment:
- nuclear matrix
- localized in speckled-like pattern
- localized with condensed chromatin at prophase
- detected in nuclear spindle poles at metaphase & in contractile ring during telophase & cytokinesis.
Alternative splicing: named isoforms=6
Expression: ubiquitous
General
cytoskeletal protein
Properties
SIZE: MW = 45 kD
entity length = 396 aa
COMPARTMENT: cell nucleus
MOTIF: cell-cell contact {1-124}
LisH {121-153}
CTLH {159-216}
Database Correlations
OMIM 606801
UniProt Q7L5Y9
References
UniProt :accession Q7L5Y9