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macroamylasemia
Etiology:
- protein-bound amylase
a) inborn macroamylasemia: attachment to albumin or globulin
b) IgA-bound:
1] celiac disease
2] lymphoma
3] immunoproliferative small bowel disease
c) IgG-bound:
1] chronic infection
2] liver disease
d) immune complex-bound:
1] AIDS
2] connective tissue disease
3] Sjogren's disease
Epidemiology:
- 2% of normal persons
Pathology:
- pancreatic amylase & salivary amylase present in variable proprotions
Laboratory:
1) the amylase-protein complex may intermittently dissociate resulting in fluctuating serum amylase levels from normal to grossly elevated
2) urine amylase is normal
Related
amylase
amylase in serum/plasma
amylase in urine
hyperamylasemia
macroamylase
General
sign/symptom
References
Medical Knowledge Self Assessment Program (MKSAP) 11, American
College of Physicians, Philadelphia 1998