L-xylulose reductase; XR; carbonyl reductase II; Dicarbonyl/L-xylulose reductase; kidney dicarbonyl reductase; kiDCR; sperm surface protein P34H (DCXR)

Function: 1) catalyzes the NADPH-dependent reduction of pentoses, tetroses, trioses, alpha-dicarbonyl compounds & L-xylulose 2) uronate cycle of glucose metabolism 3) water absorption & cellular osmoregulation in the proximal renal tubules a) produces xylitol, an osmolyte b) prevents osmolytic stress in renal tubules. Xylitol + NADP⁺ L-xylulose + NADPH Structure: - homotetramer - belongs to the short-chain dehydrogenases/reductases (SDR) family Compartment: - membrane-associated, via interaction with phosphatidylinositol (putative) Expression: - expressed in kidney, liver, epididymis > brain, lung, heart, spleen, testis Pathology: - defect in DCXR is associated with pentosuria

General

oxidoreductase phosphoprotein

Properties

SIZE: entity length = 244 aa MW = 26 kD MOTIF: acetylation site SITE: N-TERMINUS EFFECTOR-BOUND: acetyl cofactor-binding site [11-40] COFACTOR-BOUND: NADP binding site SITE: 136-136 FOR-BINDING-OF: Substrate tyrosine residue {Y149} Tyr phosphorylation site {Y149} cofactor-binding site [153-153] COFACTOR-BOUND: NADP

Database Correlations

OMIM 608347 UniProt Q7Z4W1 Pfam PF00106 Entrez Gene 51181 KEGG correlations ENZYME 1.1.1.10

References

UniProt :accession Q7Z4W1