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lysyl oxidase homolog 4 (lysyl oxidase-like protein 4, lysyl oxidase-related protein C, LOXL4, LOXC)
Function:
- modulates formation of collagenous extracellular matrix (putative) ,
Cofactor: Cu+, Cu+2
Structure:
- belongs to the lysyl oxidase family
- contains 4 SRCR domains
- contains 1 lysine tyrosylquinone, generated by condensation of epsilon-amino group of Lys with topaquinone produced by oxidation of Tyr
Compartment: secreted
Expression:
- expressed in many tissues
- highest levels in skeletal muscle, testis, pancreas
- expressed in cartilage
General
glycoprotein
metalloprotein
oxidoreductase
secreted protein
Properties
SIZE: MW = 84 kD
entity length = 756 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-24}
SRCR 1 {32-133}
MOTIF: cysteine residue {C58}
MODIFICATION: cysteine residue {C122}
cysteine residue {C71}
MODIFICATION: cysteine residue {C132}
cysteine residue {C102}
MODIFICATION: cysteine residue {C112}
cysteine residue {C112}
MODIFICATION: cysteine residue {C102}
cysteine residue {C122}
MODIFICATION: cysteine residue {C58}
cysteine residue {C132}
MODIFICATION: cysteine residue {C71}
SRCR 2 {159-287}
MOTIF: cysteine residue {C191}
MODIFICATION: cysteine residue {C276}
N-glycosylation site {N198}
cysteine residue {C204}
MODIFICATION: cysteine residue {C286}
cysteine residue {C251}
MODIFICATION: cysteine residue {C261}
cysteine residue {C261}
MODIFICATION: cysteine residue {C251}
cysteine residue {C276}
MODIFICATION: cysteine residue {C191}
cysteine residue {C286}
MODIFICATION: cysteine residue {C204}
SRCR 3 {311-411}
MOTIF: cysteine residue {C336}
MODIFICATION: cysteine residue {C400}
cysteine residue {C349}
MODIFICATION: cysteine residue {C410}
cysteine residue {C380}
MODIFICATION: cysteine residue {C390}
cysteine residue {C390}
MODIFICATION: cysteine residue {C380}
cysteine residue {C400}
MODIFICATION: cysteine residue {C336}
cysteine residue {C410}
MODIFICATION: cysteine residue {C349}
SRCR 4 {421-529}
MOTIF: cysteine residue {C450}
MODIFICATION: cysteine residue {C515}
cysteine residue {C463}
MODIFICATION: cysteine residue {C528}
cysteine residue {C497}
MODIFICATION: cysteine residue {C507}
cysteine residue {C507}
MODIFICATION: cysteine residue {C497}
cysteine residue {C515}
MODIFICATION: cysteine residue {C450}
cysteine residue {C528}
MODIFICATION: cysteine residue {C463}
Lysyl-oxidase like {533-736}
MOTIF: copper [Cu]-binding site
SITE: 611-611
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 613-613
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 615-615
MOTIF: histidine residue (3)
N-glycosylation site {N629}
Database Correlations
OMIM 607318
UniProt Q96JB6
PFAM correlations
References
UniProt :accession Q96JB6