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lysyl oxidase homolog 2 (lysyl oxidase-like protein 2, lysyl oxidase-related protein 2, lysyl oxidase-related protein WS9-14, LOXL2)
Function:
- oxidoreductase
Cofactor:
- Cu+1/Cu+2
- contains 1 lysine tyrosylquinone generated by condensation of epsilon-amino group of Lys with topaquinone produced by oxidation of Tyr
Structure:
- belongs to the lysyl oxidase family
- contains 4 SRCR domains
Compartment: secreted protein
Expression:
- expressed in many tissues
- highest expression in reproductive tissues, placenta, uterus & prostate
General
glycoprotein
metalloprotein
oxidoreductase
secreted protein
Properties
SIZE: MW = 87 kD
entity length = 774 aa
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-25}
SRCR 1 {58-159}
MOTIF: cysteine residue {C84}
MODIFICATION: cysteine residue {C148}
cysteine residue {C97}
MODIFICATION: cysteine residue {C158}
cysteine residue {C128}
MODIFICATION: cysteine residue {C138}
cysteine residue {C138}
MODIFICATION: cysteine residue {C128}
cysteine residue {C148}
MODIFICATION: cysteine residue {C84}
cysteine residue {C158}
MODIFICATION: cysteine residue {C97}
SRCR 2 {188-302}
MOTIF: cysteine residue {C218}
MODIFICATION: cysteine residue {C291}
cysteine residue {C231}
MODIFICATION: cysteine residue {C301}
cysteine residue {C265}
MODIFICATION: cysteine residue {C275}
cysteine residue {C275}
MODIFICATION: cysteine residue {C265}
N-glycosylation site {N288}
cysteine residue {C291}
MODIFICATION: cysteine residue {C218}
cysteine residue {C301}
MODIFICATION: cysteine residue {C231}
SRCR 3 {326-425}
MOTIF: cysteine residue {C351}
MODIFICATION: cysteine residue {C414}
cysteine residue {C364}
MODIFICATION: cysteine residue {C424}
cysteine residue {C395}
MODIFICATION: cysteine residue {C405}
cysteine residue {C405}
MODIFICATION: cysteine residue {C395}
cysteine residue {C414}
MODIFICATION: cysteine residue {C351}
cysteine residue {C424}
MODIFICATION: cysteine residue {C364}
SRCR 4 {435-544}
MOTIF: N-glycosylation site {N455}
cysteine residue {C464}
MODIFICATION: cysteine residue {C530}
cysteine residue {C477}
MODIFICATION: cysteine residue {C543}
cysteine residue {C511}
MODIFICATION: cysteine residue {C521}
cysteine residue {C521}
MODIFICATION: cysteine residue {C511}
cysteine residue {C530}
MODIFICATION: cysteine residue {C464}
cysteine residue {C543}
MODIFICATION: cysteine residue {C477}
Lysyl-oxidase like {548-751}
MOTIF: copper [Cu]-binding site
SITE: 626-626
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 628-628
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 630-630
MOTIF: histidine residue (3)
N-glycosylation site {N644}
Database Correlations
OMIM 606663
UniProt Q9Y4K0
PFAM correlations
References
UniProt :accession Q9Y4K0