Lysyl oxidase homolog 1; Lysyl oxidase-like protein 1; LOL (LOXL1, LOXL)

Function: - active on elastin & collagen substrates Cofactor: Copper Structure: - contains 1 lysine tyrosylquinone - the lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine - belongs to the lysyl oxidase family Compartment: secreted Pathology: - genetic variations in LOXL1 are a cause of susceptibility to exfoliation syndrome

General

oxidoreductase secreted protein

Properties

SIZE: entity length = 574 aa MW = 63 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-25} proline-rich region SITE: 261-267 MOTIF: proline residue (SEVERAL) Lysyl-oxidase like {370-574} MOTIF: cysteine residue {C395} MODIFICATION: cysteine residue {C401} cysteine residue {C401} MODIFICATION: cysteine residue {C395} cysteine residue {C448} MODIFICATION: cysteine residue {C497} copper [Cu]-binding site SITE: 449-449 MOTIF: histidine residue (3) copper [Cu]-binding site SITE: 451-451 MOTIF: histidine residue (3) copper [Cu]-binding site SITE: 453-453 MOTIF: histidine residue (3) cysteine residue {C481} MODIFICATION: cysteine residue {C487} cysteine residue {C487} MODIFICATION: cysteine residue {C481} cysteine residue {C497} MODIFICATION: cysteine residue {C448} cysteine residue {C508} MODIFICATION: cysteine residue {C518} cysteine residue {C518} MODIFICATION: cysteine residue {C508} cysteine residue {C555} MODIFICATION: cysteine residue {C569} cysteine residue {C569} MODIFICATION: cysteine residue {C555}

Database Correlations

OMIM correlations MORBIDMAP 153456 UniProt Q08397 Pfam PF01186 Entrez Gene 4016 Kegg hsa:4016

References

UniProt :accession Q08397