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lysyl oxidase or protein lysine-6-oxidase
Function:
- cross-linking of extracellular matrix proteins
- responsible for the post-translational oxidative deamination of Lys in precursors to fibrous collagen & elastin
- direct role in tumor suppression
- the Lys-Tyr quinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a Lys with a topaquinone produced by oxidation of Tyr
- propeptide plays a role in directing the deposition of enzyme to elastic fibers, via interaction with tropoelastin (putative)
peptidyl-L-lysyl-peptide + O2 + H2O
peptidyl-allysyl-peptide + NH3 + H2O2
Cofactor: Copper
Structure:
- belongs to the lysyl oxidase family
- contains 1 lysine tyrosylquinone (putative)
Compartment: secreted, extracellular space
Expression:
- heart, placenta, skeletal muscle, kidney, lung & pancreas
Pathology:
- defects in LOX may be a cause of autosomal recessive cutis laxa type 1
General
amino-acid oxidoreductase
glycoprotein
secreted protein
Properties
SIZE: entity length = 417 aa
MW = 47 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-21}
N-glycosylation site {N81}
N-glycosylation site {N97}
N-glycosylation site {N144}
Lysyl-oxidase like {213-417}
MOTIF: copper [Cu]-binding site
SITE: 292-292
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 294-294
MOTIF: histidine residue (3)
copper [Cu]-binding site
SITE: 296-296
MOTIF: histidine residue (3)
Database Correlations
OMIM correlations
UniProt P28300
Pfam PF01186
Kegg hsa:4015
ENZYME 1.4.3.13
References
UniProt :accession P28300