lysophosphatidic acid receptor Edg-4; LPA receptor 2; LPA-2 (EDG4, LPAR2, LPA2)

Function: - receptor for lysophosphatidic acid - mediator of diverse cellular activities - coupled to the Gi/Go G12/G13, & Gq families of heteromeric G proteins - role in phospholipase C-beta (PLC-beta) signaling pathway - interacts with SLC9A3R2/NHERF2 & PLCB3 Structure: - belongs to the G-protein coupled receptor 1 family Compartment: membrane Expression: - expressed in testes & peripheral blood leukocytes > pancreas, spleen, thymus, prostate - little or no expression in heart, brain, placenta, lung, liver, skeletal muscle, kidney, ovary, small intestine, or colon

General

glycoprotein lysophosphatidic acid receptor (LPA-R)

Properties

SIZE: MW = 39 kD entity length = 351 aa COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-33} MOTIF: N-glycosylation site {N10} N-glycosylation site {N18} transmembrane domain {34-54} cytoplasmic loop {55-69} transmembrane domain {70-90} exoplasmic loop {91-103} transmembrane domain {104-126} cytoplasmic loop {127-146} transmembrane domain {147-167} exoplasmic loop {168-188} transmembrane domain {189-209} cytoplasmic loop {210-242} transmembrane domain {243-263} exoplasmic loop {264-279} transmembrane domain {280-297} cytoplasmic domain {298-351} MOTIF: cysteine residue {C311} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 605110 UniProt Q9HBW0 Pfam PF00001

References

UniProt :accession Q9HBW0