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sphingosine 1-phosphate receptor 3; S1P receptor 3; S1P3; sphingosine 1-phosphate receptor Edg-3; S1P receptor Edg-3; endothelial differentiation G-protein coupled receptor 3 (S1PR3, EDG3)
Function:
- receptor for the lysosphingolipid sphingosine 1-phosphate (S1P)
- when expressed in rat HTC4 hepatoma cells, capable of mediating S1P-induced cell proliferation & suppression of apoptosis
Structure: belongs to the G-protein coupled receptor 1 family
Compartment: cell membrane
Expression:
- expressed in all tissues
- expressed most abundantly in heart, placenta, kidney, & liver
General
glycoprotein
lysophosphatidic acid receptor (LPA-R)
sphingosine 1-phosphate receptor; S1P receptor (S1PR)
Properties
SIZE: entity length = 378 aa
MW = 42 kD
COMPARTMENT: cellular membrane
MOTIF: exoplasmic domain {1-40}
MOTIF: N-glycosylation site {N15}
transmembrane domain {41-65}
cytoplasmic loop {66-72}
transmembrane domain {73-101}
exoplasmic loop {102-115}
transmembrane domain {116-134}
cytoplasmic loop {135-153}
transmembrane domain {154-179}
exoplasmic loop {180-195}
transmembrane domain {196-216}
cytoplasmic loop {217-243}
transmembrane domain {244-265}
exoplasmic loop {266-281}
transmembrane domain {282-302}
cytoplasmic domain {303-378}
Database Correlations
OMIM 601965
UniProt Q99500
Pfam PF00001
Kegg hsa:1903
References
UniProt :accession Q99500