Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2 (LPAR1, EDG2, LPA1)

Function: - receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities - seems to be coupled to Gi proteins, Go proteins, G12 proteins, & Gq proteins Structure: belongs to the G-protein coupled receptor 1 family Compartment: cell membrane Expression: - expressed in many adult organs, including brain, heart, colon, small intestine, placenta, prostate, ovary, pancreas, testes, spleen, skeletal muscle, & kidney - little or no expression in liver, lung, thymus, or peripheral blood leukocytes

General

glycoprotein lysophosphatidic acid receptor (LPA-R)

Properties

SIZE: entity length = 364 aa MW = 41 kD COMPARTMENT: cellular membrane MOTIF: exoplasmic domain {1-50} MOTIF: N-glycosylation site {N27} N-glycosylation site {N35} transmembrane domain {51-75} cytoplasmic loop {76-82} transmembrane domain {83-111} exoplasmic loop {112-125} transmembrane domain {126-144} cytoplasmic loop {145-163} transmembrane domain {164-189} exoplasmic loop {190-205} transmembrane domain {206-226} cytoplasmic loop {227-258} transmembrane domain {259-280} exoplasmic loop {281-294} transmembrane domain {295-315} cytoplasmic domain {316-364} MOTIF: cysteine residue {C327} MODIFICATION: palmitate COMPARTMENT: membrane

Database Correlations

OMIM 602282 UniProt Q92633 Pfam PF00001 Kegg hsa:1902

References

UniProt :accession Q92633