lysine-specific demethylase 4F (KDM4F)

Function: - probable histone demethylase - specifically demethylates 'Lys-9' of histone H3, thus playing a central role in histone code 2 2-oxoglutarate + N(6),N(6),N(6)-trimethyl-L-lysyl(9)-[histone H3] + 2 O₂ = 2 CO₂ + 2 formaldehyde + N(6)-methyl-L-lysyl(9)-[histone H3] + 2 succinate Cofactor: Fe⁺² (binds 1 Fe⁺² ion per subunit) Structure: - belongs to the JHDM3 histone demethylase family Compartment: nucleus

Properties

SIZE: entity length = 638 aa MW = 71 kD COMPARTMENT: cell nucleus MOTIF: binding site SITE: 133-133 MOTIF: binding site SITE: 133-133 binding site SITE: 189-189 MOTIF: binding site SITE: 189-189 binding site SITE: 191-191 MOTIF: binding site SITE: 191-191 binding site SITE: 199-199 MOTIF: binding site SITE: 199-199 binding site SITE: 207-207 MOTIF: binding site SITE: 207-207 binding site SITE: 235-235 MOTIF: binding site SITE: 235-235 binding site SITE: 241-241 MOTIF: binding site SITE: 241-241 binding site SITE: 242-242 MOTIF: binding site SITE: 242-242 binding site SITE: 277-277 MOTIF: binding site SITE: 277-277 binding site SITE: 307-307 MOTIF: binding site SITE: 307-307 binding site SITE: 309-309 MOTIF: binding site SITE: 309-309

Database Correlations

UniProt A0A1W2PPD8 PFAM correlations ENZYME 1.14.11.66

References

UniProt :accession A0A1W2PPD8