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lysine-specific demethylase 4D-like; KDM4D-like protein (KDM4DL, KDM4E)
Function:
- probable histone demethylase
- demethylation of Lys generates formaldehyde & succinate (putative)
Cofactor: binds 1 Fe+2 ion per subunit (putative)
Structure:
- belongs to the JHDM3 histone demethylase family
- contains 1 JmjC domain
- contains 1 JmjN domain
Compartment: nucleus (putative)
General
histone demethylase
oxidoreductase
Properties
SIZE: entity length = 506 aa
MW = 57 kD
COMPARTMENT: cell nucleus
MOTIF: JmjN {15-57}
lysine-rich region {88-91}
MOTIF: lysine residue (SEVERAL)
binding site
SITE: 133-133
FOR-BINDING-OF: Alpha-ketoglutarate
JmjC {143-309}
MOTIF: Iron [Fe]-binding site
SITE: 189-189
Iron [Fe]-binding site
SITE: 191-191
binding site
SITE: 199-199
FOR-BINDING-OF: Alpha-ketoglutarate
binding site
SITE: 207-207
FOR-BINDING-OF: Alpha-ketoglutarate
Zn+2-binding site
SITE: 235-235
Zn+2-binding site
SITE: 241-241
Iron [Fe]-binding site
SITE: 277-277
Zn+2-binding site
SITE: 307-307
Zn+2-binding site
SITE: 309-309
Database Correlations
UniProt B2RXH2
PFAM correlations
Entrez Gene 390245
Kegg hsa:390245
References
UniProt :accession B2RXH2