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lymphotoxin alpha/beta receptor; tumor necrosis factor receptor superfamily member 3; lymphotoxin-beta receptor; tumor necrosis factor receptor 2-related protein; tumor necrosis factor C receptor (LTBR, D12S370, TNFCR, TNFRSF3)
Function:
- receptor for the heterotrimeric lymphotoxin containing LTA & LTB, & for TNFS14/LIGHT
- promotes apoptosis via TRAF3 & TRAF5
- may play a role in development of lymphoid organs
- self-associates
- associates with TRAF3, TRAF4 & TRAF5
- interacts with HCV core protein
Structure: contains 4 TNFR-cys repeats
Compartment: membrane
General
glycoprotein
tumor necrosis factor [TNF] receptor family
Properties
SIZE: entity length = 435 aa
MW = 47 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-30}
N-glycosylation site {N40}
TNFR-Cys {42-81}
MOTIF: cysteine residue {C43}
MODIFICATION: cysteine residue {C58}
cysteine residue {C58}
MODIFICATION: cysteine residue {C43}
cysteine residue {C59}
MODIFICATION: cysteine residue {C72}
cysteine residue {C62}
MODIFICATION: cysteine residue {C80}
cysteine residue {C72}
MODIFICATION: cysteine residue {C59}
cysteine residue {C80}
MODIFICATION: cysteine residue {C62}
TNFR-Cys {82-124}
MOTIF: cysteine residue {C83}
MODIFICATION: cysteine residue {C98}
cysteine residue {C98}
MODIFICATION: cysteine residue {C83}
cysteine residue {C101}
MODIFICATION: cysteine residue {C116}
cysteine residue {C104}
MODIFICATION: cysteine residue {C124}
cysteine residue {C116}
MODIFICATION: cysteine residue {C101}
cysteine residue {C124}
MODIFICATION: cysteine residue {C104}
TNFR-Cys {125-168}
MOTIF: cysteine residue {C126}
MODIFICATION: cysteine residue {C132}
cysteine residue {C132}
MODIFICATION: cysteine residue {C126}
cysteine residue {C139}
MODIFICATION: cysteine residue {C148}
cysteine residue {C142}
MODIFICATION: cysteine residue {C167}
cysteine residue {C148}
MODIFICATION: cysteine residue {C139}
cysteine residue {C167}
MODIFICATION: cysteine residue {C142}
TNFR-Cys {169-211}
MOTIF: cysteine residue {C170}
MODIFICATION: cysteine residue {C185}
N-glycosylation site {N177}
cysteine residue {C185}
MODIFICATION: cysteine residue {C170}
transmembrane domain {228-248}
Database Correlations
OMIM 600979
UniProt P36941
Pfam PF00020
Entrez Gene 4055
Kegg hsa:4055
References
UniProt :accession P36941