lymphocyte antigen 96; Ly-96; ESOP-1; protein MD-2 (LY96, ESOP1 MD2)

Function: 1) cooperates with TLR4 in the innate immune response to bacterial lipopolysaccharide (LPS) 2) cooprerates with TLR2 in the response to cell wall components Gram-positive & Gram-negative bacteria 3) enhances TLR4-dependent activation of NF-kappa-B 4) component of lipopolysaccharide receptor (LPS receptor) 5) cells expressing both MD2 & TLR4, but not TLR4 alone, respond to LPS 6) binds to the extracellular domains of TLR2 & TLR4 - ligand binding induces interaction with TLR4 & oligomerization of the LPS receptor complex Structure: - heterogeneous homopolymer formed from homodimers, disulfide-linked - N-glycosylated, high-mannose Compartment: secreted

Related

Toll-like receptor 2; Toll/interleukin-1 receptor-like protein 4; CD282 (TLR2, TIL4) Toll-like receptor 3; CD283 (TLR3)

General

glycoprotein secreted protein

Properties

SIZE: entity length = 160 aa MW = 19 kD COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} cysteine residue {C25} MODIFICATION: cysteine residue {C51} N-glycosylation site {N26} cysteine residue {C37} MODIFICATION: cysteine residue {C148} cysteine residue {C51} MODIFICATION: cysteine residue {C25} cysteine residue {C95} MODIFICATION: cysteine residue {C105} cysteine residue {C105} MODIFICATION: cysteine residue {C95} N-glycosylation site {N114} lipopolysaccharide interaction {119-123} cysteine residue {C148} MODIFICATION: cysteine residue {C37}

Database Correlations

OMIM 605243 UniProt Q9Y6Y9 Pfam PF02221 Entrez Gene 23643 Kegg hsa:23643

References

UniProt :accession Q9Y6Y9