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lymphocyte antigen 86; Ly-86; protein MD-1 (LY86, MD1)
Function:
1) cooperates with CD180 & TLR4 to mediate innate immune response to bacterial lipopolysaccharide (LPS) & cytokine production (putative)
2) role in efficient CD180 cell surface expression
3) M-shaped tetramer of two CD180-LY86 heterodimers
Compartment:
- secreted, extracellular space
- associated with CD180 at the cell surface
Expression:
- expressed in B-cells, monocytes & in pallatine tonsil
Pathology:
- down-regulated in monocytes by the cell-wall fraction of Mycobacterium bovis
General
glycoprotein
human longevity protein
secreted protein
Properties
SIZE: entity length = 162 aa
MW = 18 kD
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-20}
cysteine residue {C33}
MODIFICATION: cysteine residue {C58}
cysteine residue {C45}
MODIFICATION: cysteine residue {C154}
cysteine residue {C58}
MODIFICATION: cysteine residue {C33}
N-glycosylation site {N96}
cysteine residue {C102}
MODIFICATION: cysteine residue {C112}
cysteine residue {C112}
MODIFICATION: cysteine residue {C102}
cysteine residue {C154}
MODIFICATION: cysteine residue {C45}
N-glycosylation site {N156}
Database Correlations
OMIM 605241
UniProt O95711
Pfam PF02221
Entrez Gene 9450
Kegg hsa:9450
References
UniProt :accession O95711