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lymphocyte antigen 6 complex locus protein G6f (LY6G6F, C6orf21, G6F, NG32)
Function:
- may play a role in the downstream signal transduction pathways involving GRB2 & GRB7
- interacts with GRB2 & GRB7 (phosphorylation-dependent)
Structure:
- N-glycosylated
- homodimer; disulfide-linked
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: plasma membrane; single-pass type 1 membrane protein
Alternative splicing: named isoforms=2
General
glycoprotein
human longevity protein
membrane protein
phosphoprotein
Properties
SIZE: entity length = 297 aa
MW = 32 kD
COMPARTMENT: plasma membrane
MOTIF: signal sequence {1-16}
immunoglobulin superfamily domain {17-122}
MOTIF: cysteine residue {C35}
MODIFICATION: cysteine residue {C106}
N-glycosylation site {N88}
cysteine residue {C106}
MODIFICATION: cysteine residue {C35}
transmembrane domain {236-256}
Tyr phosphorylation site {Y281}
Database Correlations
OMIM 611404
UniProt Q5SQ64
Pfam PF07686
Entrez Gene 259215
Kegg hsa:259215
References
UniProt :accession Q5SQ64