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lymphocyte activation gene 3 protein; LAG-3; FDC protein; CD223 (LAG3, FDC)
Function:
- role in lymphocyte activation
- binds to HLA class-II antigens
Structure:
- contains 3 Ig-like C2-type domains (immunoglobulin-like)
- contains 1 Ig-like V-type domain (immunoglobulin-like)
Compartment: plasma membrane; single-pass type 1 membrane protein
Expression: expressed onn cell surface of activated NK cells & T-lymphocytes
General
cluster-of-differentiation antigen; cluster designation antigen; CD antigen
glycoprotein
Properties
SIZE: entity length = 525 aa
MW = 57 kD
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-28}
immunoglobulin superfamily domain {37-167}
MOTIF: cysteine residue {C44}
MODIFICATION: cysteine residue {C160}
cysteine residue {C160}
MODIFICATION: cysteine residue {C44}
immunoglobulin superfamily domain {168-252}
MOTIF: N-glycosylation site {N188}
cysteine residue {C189}
MODIFICATION: cysteine residue {C241}
cysteine residue {C241}
MODIFICATION: cysteine residue {C189}
N-glycosylation site {N250}
N-glycosylation site {N256}
immunoglobulin superfamily domain {265-343}
MOTIF: cysteine residue {C282}
MODIFICATION: cysteine residue {C333}
cysteine residue {C333}
MODIFICATION: cysteine residue {C282}
N-glycosylation site {N343}
immunoglobulin superfamily domain {348-419}
MOTIF: cysteine residue {C369}
MODIFICATION: cysteine residue {C412}
cysteine residue {C412}
MODIFICATION: cysteine residue {C369}
transmembrane domain {451-471}
12 X 2 AA tandem repeats of E-X {501-524}
Database Correlations
OMIM 153337
UniProt P18627
PFAM correlations
Entrez Gene 3902
Kegg hsa:3902
References
UniProt :accession P18627