lymphatic vessel endothelial hyaluronic acid receptor 1; LYVE-1; cell surface retention sequence-binding protein 1; CRSBP-1 hyaluronic acid receptor; extracellular link domain-containing protein 1 (XLKD1, LYVE1, CRSBP1, HAR, UNQ230/PRO263)

Function: 1) ligand-specific transporter trafficking between intracellular organelles (trans Golgi) & the plasma membrane 2) role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding 3) hyaluronan transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake & degradation in lymph nodes 4) interacts with PDGFB & IGFBP3 5) forms a transient ternary complex with PDGFB & PDGFRB in trans Golgi Structure: - homodimer, disulfide-linked - O-glycosylated - contains 1 Link domain Compartment: - plasma membrane, trans-Golgi, endosomes - undergoes ligand-dependent internalization & recycling at cell surface Expression: - expressed in endothelial cells lining lymphatic vessels

General

carrier protein (transporter) cell surface receptor glycoprotein

Properties

SIZE: MW = 35 kD entity length = 322 aa COMPARTMENT: nuclear membrane golgi MOTIF: signal sequence {1-19} Link {40-130} MOTIF: N-glycosylation site {N53} cysteine residue {C61} MODIFICATION: cysteine residue {C128} cysteine residue {C85} MODIFICATION: cysteine residue {C106} cysteine residue {C106} MODIFICATION: cysteine residue {C85} cysteine residue {C128} MODIFICATION: cysteine residue {C61} N-glycosylation site {N130} transmembrane domain {239-259}

Database Correlations

OMIM 605702 UniProt Q9Y5Y7 Pfam PF00193

References

UniProt :accession Q9Y5Y7