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lyl-1 proto-oncogene protein; lymphoblastic leukemia-derived sequence 1 (LYL1)
Function:
- efficient DNA binding requires dimerization with another bHLH protein
Structure: contains 1 basic helix-loop-helix (bHLH) domain
Compartment: nucleus (putative)
Pathology:
- chromosomal translocation t(7;19)(q35;p13) involving LYL1 with TCRB is associated with T-cell acute lymphoblastic leukemia (T-ALL)
Related
lyl-1 proto-oncogene
General
basic helix loop helix (bHLH) family transcription factor
proto oncogene protein
transcription factor (TF)
Properties
SIZE: entity length = 267 aa
MW = 29 kD
COMPARTMENT: cell nucleus
MOTIF: DNA-binding motif
SITE: 137-149
helix-loop-helix
NAME: helix-loop-helix
SITE: 150-190
FOR-BINDING-VIA: helix-loop-helix
Database Correlations
OMIM 151440
UniProt P12980
Pfam PF00010
Kegg hsa:4066
References
- Hunter T.
Cooperation between oncogenes.
Cell. 1991 Jan 25;64(2):249-70. Review.
PMID: 1988147
- Atlas of genetics & cytogenetics in oncology & haematology
http://atlasgeneticsoncology.org/genes/LYL1ID51ch19p13.html
- UniProt :accession P12980