LY295427

Synthetic sterol. Mechanism of action: 1) reduces plasma cholesterol by increasing expression of LDL receptor 2) reverses oxysterol-induced suppression of sterol regulatory element binding protein (SREBP) processing

Related

low-density lipoprotein receptor; LDL receptor; apoB/E receptor (LDLR) sterol regulatory element binding protein (SREBP)

General

anti-hyperlipidemic agent sterol

References

- Janowskii et al, The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem 276:45408, 2001 PMID: 11577112