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LY2140023 (LY404039)
Indications:
- experimental drug used to treat schizophrenia
Pharmacokinetics:
- prodrug hydrolyzed to LY404039
Mechanism of action:
- LY404039 is a metabotropic glutamate receptor agonist specific for mGluR2 & mGluR3
Interactions
drug adverse effects of antipsychotic agents
monitor with atypical antipsychotic agents
General
atypical antipsychotic agent; second generation antipsychotic
References
- Patil ST et al
Activation of mGlu2/3 receptors as a new approach to treat
schizophrenia: A randomized phase 2 clinical trial.
Nat Med 2007 Sep; 13:1102.
PMID: 17767166
- Weinberger DR.
Schizophrenia drug says goodbye to dopamine.
Nat Med 2007 Sep; 13:1018.
PMID: 17828217