LX nuclear receptor (LXR, oxysterol receptor)

alpha & beta forms. Ligands are oxysterols. LXR binds to RXR to form heterodimers which bind to & activates LXRE enhancer elements.

Related

LX response element (LXRE) oxysterol; hydroxysterol retinoid X receptor (RXR)

Specific

Oxysterols receptor LXR-alpha; liver X receptor alpha; nuclear orphan receptor LXR-alpha; nuclear receptor subfamily 1 group H member 3 (NR1H3, LXRA) oxysterols receptor LXR-beta; liver X receptor beta; nuclear orphan receptor LXR-beta; nuclear receptor subfamily 1 group H member 2; ubiquitously-expressed nuclear receptor; nuclear receptor NER (NR1H2, LXRB, NER, UNR)

General

nuclear hormone receptor NR1 subfamily redox-modulated transcription factor zinc finger protein

Properties

COMPARTMENT: cytoplasm MOTIF: allosteric site DNA-binding motif MOTIF: kxffkr NAME: kxffkr FOR-BINDING-OF: calreticulin FORM: kxffkr Zinc finger NAME: Zinc finger (2) EFFECTOR-BOUND: Zn+2 ligand-binding site

References

- Laffitte BA et al LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes, Proc Natl Acad Sci USA 2001, 98:507 PMID: 11149950