Lutheran blood group glycoprotein; B-CAM cell surface glycoprotein; Auberger B antigen; F8/G253 antigen; CD239 antigen (BCAM, LU, MSK19)

Function: 1) probable receptor Compartment: membrane Expression: - wide tissue distribution (highest in pancreas, very low in brain) - associated with the basal layer of cells in epithelia & endothelium of blood vessels - under developmental control in liver Pathology: up-regulated following malignant transformation in some cells

General

cell surface receptor glycoprotein

Properties

SIZE: MW = 67 kD entity length = 628 aa COMPARTMENT: plasma membrane MOTIF: signal sequence {1-31} immunoglobulin superfamily domain {32-142} MOTIF: cysteine residue {C53} MODIFICATION: cysteine residue {C125} cysteine residue {C125} MODIFICATION: cysteine residue {C53} immunoglobulin superfamily domain {147-257} MOTIF: cysteine residue {C172} MODIFICATION: cysteine residue {C237} cysteine residue {C237} MODIFICATION: cysteine residue {C172} immunoglobulin superfamily domain {274-355} MOTIF: cysteine residue {C291} MODIFICATION: cysteine residue {C337} N-glycosylation site {N321} cysteine residue {C337} MODIFICATION: cysteine residue {C291} immunoglobulin superfamily domain {363-441} MOTIF: N-glycosylation site {N377} N-glycosylation site {N383} cysteine residue {C384} MODIFICATION: cysteine residue {C424} N-glycosylation site {N419} cysteine residue {C424} MODIFICATION: cysteine residue {C384} N-glycosylation site {N439} immunoglobulin superfamily domain {448-541} MOTIF: cysteine residue {C473} MODIFICATION: cysteine residue {C522} cysteine residue {C522} MODIFICATION: cysteine residue {C473} transmembrane domain {548-568}

Database Correlations

OMIM 111200 UniProt P50895 PFAM correlations

References

UniProt :accession P50895