Lupus La protein; Sjoegren syndrome type B antigen; SS-B; La ribonucleoprotein; La autoantigen (SSB)

Function: - La protein plays a role in the transcription of RNA polymerase 3 - it is most probably a transcription termination factor - binds to the 3' termini of virtually all nascent RNA polymerase 3 transcripts - associated with precursor forms of RNA polymerase 3 transcripts including tRNA & 4.5S, 5S, 7S, & 7-2 RNAs - phosphorylated - interacts with DDX15 - may interact with RUFY1 Structure: - phosphorylation sites are at the C-terminal part of the protein - the N-terminus is blocked - contains 1 HTH La-type RNA-binding domain - contains 1 RRM domain (RNA recognition motif) Compartment: nucleus (probable) Pathology: - sera from patients with systemic lupus erythematosus (SLE) often contain La protein autoantibodies (anti-SSB)

General

antigen nuclear protein phosphoprotein RNA-binding protein

Properties

SIZE: entity length = 408 aa MW = 47 kD COMPARTMENT: cell nucleus MOTIF: RNA-binding motif SITE: 7-99 FOR-BINDING-OF: ribonucleic acid RNP motif NAME: RNP motif SITE: 111-187 FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif NAME: ribonucleoprotein-1 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif ribonucleoprotein-2 motif FOR-BINDING-OF: ribonucleic acid MOTIF: ribonucleoprotein-1 motif ribonucleoprotein-2 motif Ser phosphorylation site {S366}

Database Correlations

OMIM 109090 UniProt P05455 PFAM correlations Entrez Gene 6741 Kegg hsa:6741

References

UniProt :accession P05455