lumican (keratan sulfate proteoglycan lumican, KSPG lumican, LUM, LDC)

Function: 1) binds to laminin Structure: - contains 12 LRR (leucine-rich repeats) Compartment: secreted, extracellular matrix Expression: - expressed in cornea & other tissues - present in the extracellular matrix of human articular cartilage at all ages - abundance is far greater in the adult - in adult cartilage, lumican exists largely as glycoprotein lacking keratan sulfate; the juvenile form is a proteoglycan

General

glycoprotein secreted protein

Properties

SIZE: MW = 38 kD entity length = 338 aa COMPARTMENT: extracellular compartment MOTIF: signal sequence {1-18} cysteine-rich region {37-53} leucine-rich repeat SITE: 59-78 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 79-102 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N88} leucine-rich repeat SITE: 103-128 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N127} leucine-rich repeat SITE: 129-149 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 150-171 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N160} leucine-rich repeat SITE: 172-196 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 197-217 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 218-241 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 242-266 MOTIF: leucine residue (SEVERAL) N-glycosylation site {N252} leucine-rich repeat SITE: 267-286 MOTIF: leucine residue (SEVERAL) leucine-rich repeat SITE: 287-316 MOTIF: leucine residue (SEVERAL) cysteine residue {C295} MODIFICATION: cysteine residue {C328} leucine-rich repeat SITE: 317-338 MOTIF: leucine residue (SEVERAL) cysteine residue {C328} MODIFICATION: cysteine residue {C295}

Database Correlations

OMIM 600616 UniProt P51884 PFAM correlations

References

UniProt :accession P51884