Contents

Search

Lugol's solution (iodine/iodide)

5% iodine/ 10% iodide. Contraindications: Pregnancy category: D Adverse effects: - not common (> 10%) - angioedema, fever, headache, urticaria, acne, goiter with hypothyroidism, metallic taste, GI upset, cutaneous & mucosal hemorrhage, eosinophilia, arthralgia, lymph node enlargement, soreness of teeth & gums, rhinitis Mechanism of action: Iodide limits its own transport & inhibits synthesis of iodotyrosine & iodothyronine. Intracellular iodide concentration appears to be the major determinant. This phenomenon is known as the Wolf-Chaikoff effect (1948). The iodine is reduced to iodide in the intestine before absorbtion.

General

thyroid agent pharmacologic combination

Database Correlations

PUBCHEM cid=105053

References

  1. The Pharmacological Basis of Therapeutics, 9th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1996.
  2. Goodman and Gilman's The Pharmacological Basis of Therapeutics, 8th ed. Gilman et al, eds. Permagon Press/McGraw Hill, 1990. pg 1014-6
  3. Kaiser Permanente Northern California Regional Drug Formulary, 1998

Components

I- (iodide) iodine [I]