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lipopolysaccharide-binding protein (LBP)
Function:
- binds to the lipid A moiety of bacterial lipopolysaccharide (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria
- the LBP/LPS complex seems to interact with the CD14 receptor
Structure:
- belongs to the BPI/LBP/plunc superfamily, BPI/LBP family
Compartment: secreted
Laboratory:
- lipopolysaccharide-binding protein in serum/plasma
Interactions
molecular events
General
glycoprotein
opsonin
Properties
SIZE: entity length = 481 aa
MW = 53 kD
COMPARTMENT: plasma
MOTIF: signal sequence {1-25}
N-glycosylation site {N300}
N-glycosylation site {N355}
N-glycosylation site {N386}
N-glycosylation site {N394}
Database Correlations
OMIM 151990
UniProt P18428
PFAM correlations
Entrez Gene 3929
Kegg hsa:3929
References
- UniProt :accession P18428
- Wright SD et al
CD14, a receptor for complexes of lipopolysaccharide (LPS) and
LPS binding protein.
Science 249:1431 1990
PMID: 1698311
Component-of
molecular complex