lectin-like Ox-LDL receptor (LOX-1)

Receptor for oxidatively modified low density lipoprotein, member of C-type lectin family, expressed in vascular endothelium & vascular-rich organs.

General

cell surface receptor C-type (calcium dependent, carbohydrate-recognition domain) lectin superfamily or C-type lectin domain family

Properties

SIZE: entity length = 273 aa MW = 30.9 kD COMPARTMENT: plasma membrane MOTIF: Thr phosphorylation site {T2} FOR-PHOSPHORYLATION-BY: casein kinase 2 Thr phosphorylation site {T21} FOR-PHOSPHORYLATION-BY: protein kinase C Ser phosphorylation site {S28} FOR-PHOSPHORYLATION-BY: protein kinase C transmembrane domain {35-60} carbohydrate-recognition domain {144-272} MOTIF: cysteine residue {*1} (3) MODIFICATION: cysteine residue {*2} cysteine residue {*2} (3) MODIFICATION: cysteine residue {*1}

References

- Sawamura T et al An endothelial receptor for oxidized low-density lipoprotein. Nature 386:73-77 1997 PMID: 9052782