low-intensity alternating electric field (AEF)

Indications: - treatment of glioblastoma multiforme Procedure: - scalp for - placement of 4 transducers onto the scalp, worn at least 18 hours a day - attached to a portable power supply Mechanism of action: - seems to disrupt spindle formation during mitosis

References

Stupp R et al Maintenance Therapy With Tumor-Treating Fields Plus Temozolomide vs Temozolomide Alone for GlioblastomaA Randomized Clinical Trial. JAMA. 2015;314(23):2535-2543 PMID: 26670971 http://jama.jamanetwork.com/article.aspx?articleid=2475463 - Sampson JH Alternating Electric Fields for the Treatment of Glioblastoma. JAMA. 2015;314(23):2511-2513 PMID: 26670969 http://jama.jamanetwork.com/article.aspx?articleid=2475446