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lorundrostat
Indications:
- refractory hypertension (investigational) [1]
Dosage: 50-100 mg PO QD
Adverse effects:
- hyperkalemia
Mechanism of action:
- aldosterone synthase inhibitor
Interactions
drug adverse effects of renin-angiotensin-aldosterone system inhibitors (RAAS inhibitors)
General
aldosterone receptor antagonist (aldosterone antagonist)
Database Correlations
PUBCHEM cid=126567187
References
- Laffin LJ, Rodman D, Luther JM et al
Aldosterone Synthase Inhibition With Lorundrostat for Uncontrolled Hypertension.
The Target-HTN Randomized Clinical Trial.
JAMA. 2023;330(12):1140-1150.
PMID: 37690061 PMCID: PMC10493865 Free PMC article
https://jamanetwork.com/journals/jama/fullarticle/2809625