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liver carboxylesterase; carboxylesterase 1; monocyte/macrophage serine esterase 1; acyl coenzyme A:cholesterol acyltransferase; ACAT; triacylglycerol hydrolase; TGH; Egasyn; brain carboxylesterase hBr1 (CES1, CES2)
Function:
1) detoxification of xenobiotics
2) activation of ester & amide prodrugs
3) hydrolyzes aromatic & aliphatic esters
4) no catalytic activity toward amides or fatty acyl CoA ester
5) binds to beta-glucuronidase
Structure:
- homotrimer, homohexamer
- contains sialic acid
Compartment: endoplasmic reticulum lumen
Expression: expressed in liver > heart, lung
Laboratory:
- CES1 gene c.428G>A
General
carboxylase (carboxylic ester hydrolase)
glycoprotein
Properties
SIZE: MW = 63 kD
entity length = 567 aa
COMPARTMENT: endoplasmic reticulum
MOTIF: signal sequence {1-18}
N-glycosylation site {N79}
cysteine residue {C87}
MODIFICATION: cysteine residue {C116}
cysteine residue {C116}
MODIFICATION: cysteine residue {C87}
serine residue {S221}
cysteine residue {C274}
MODIFICATION: cysteine residue {C285}
cysteine residue {C285}
MODIFICATION: cysteine residue {C274}
glutamate residue {E354}
histidine residue {H468}
Database Correlations
OMIM 114835
MORBIDMAP 114835
UniProt P23141
Pfam PF00135
Entrez Gene 1066
Kegg hsa:1066
ENZYME 3.1.1.1
References
UniProt :accession P23141