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lipoyltransferase 1, mitochondrial; lipoate biosynthesis protein; lipoate-protein ligase; lipoyl ligase (LIPT1)
Function:
1) lipoate biosynthesis
2) catalyzes transfer of the lipoyl group from lipoyl-AMP to Lys of the lipoate-dependent enzymes
Structure: belongs to the lplA family
Compartment: mitochondrion
Expression:
- expressed in skeletal muscle, heart > kidney, pancreas > liver, brain, placenta, lung
General
ligase or synthetase
mitochondrial protein
transferase
Properties
SIZE: entity length = 373 aa
MW = 42 kD
COMPARTMENT: mitochondria
MOTIF: binding site
SITE: 107-107
FOR-BINDING-OF: Substrate
binding site
SITE: 151-151
FOR-BINDING-OF: Substrate
binding site
SITE: 161-161
FOR-BINDING-OF: Substrate
binding site
SITE: 179-179
FOR-BINDING-OF: Substrate
Database Correlations
OMIM 610284
UniProt Q9Y234
Pfam PF03099
Entrez Gene 51601
Kegg hsa:51601
References
- UniProt :accession Q9Y234