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lipopolysaccharide (LPS) receptor
Receptor for bacterial polysaccharide.
Structure:
- consists of CD14, LY96, TLR4
Related
lipopolysaccharide
General
cell surface receptor
molecular complex
Properties
COMPARTMENT: plasma membrane
MOTIF: ligand-binding site
transmembrane domain
SUBUNITS: monocyte differentiation antigen CD14
MOTIF: signal sequence {1-19}
cysteine residue {C25}
MODIFICATION: cysteine residue {C36}
cysteine residue {C34}
MODIFICATION: cysteine residue {C51}
cysteine residue {C36}
MODIFICATION: cysteine residue {C25}
N-glycosylation site {N37}
cysteine residue {C51}
MODIFICATION: cysteine residue {C34}
leucine-rich repeat
SITE: 54-82
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 83-118
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 119-144
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 145-172
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N151}
leucine-rich repeat
SITE: 173-196
MOTIF: leucine residue (SEVERAL)
cysteine residue {C187}
MODIFICATION: cysteine residue {C217}
leucine-rich repeat
SITE: 197-224
MOTIF: leucine residue (SEVERAL)
cysteine residue {C217}
MODIFICATION: cysteine residue {C187}
leucine-rich repeat
SITE: 225-251
MOTIF: leucine residue (SEVERAL)
cysteine residue {C241}
MODIFICATION: cysteine residue {C272}
leucine-rich repeat
SITE: 252-278
MOTIF: leucine residue (SEVERAL)
cysteine residue {C272}
MODIFICATION: cysteine residue {C241}
leucine-rich repeat
SITE: 279-299
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N282}
leucine-rich repeat
SITE: 300-321
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 322-349
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N323}
glycosyl phosphatidylinositol [GPI] membrane anchor {N345}
lymphocyte antigen 96
COMPARTMENT: extracellular compartment
MOTIF: signal sequence {1-18}
cysteine residue {C25}
MODIFICATION: cysteine residue {C51}
N-glycosylation site {N26}
cysteine residue {C37}
MODIFICATION: cysteine residue {C148}
cysteine residue {C51}
MODIFICATION: cysteine residue {C25}
cysteine residue {C95}
MODIFICATION: cysteine residue {C105}
cysteine residue {C105}
MODIFICATION: cysteine residue {C95}
N-glycosylation site {N114}
lipopolysaccharide interaction {119-123}
cysteine residue {C148}
MODIFICATION: cysteine residue {C37}
Toll-like receptor 4
COMPARTMENT: cellular membrane
MOTIF: signal sequence {1-23}
cysteine residue {C29}
MODIFICATION: cysteine residue {C40}
N-glycosylation site {N35}
cysteine residue {C40}
MODIFICATION: cysteine residue {C29}
leucine-rich repeat
SITE: 52-76
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 77-100
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 101-124
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 128-149
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 150-173
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N173}
leucine-rich repeat
SITE: 174-197
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 203-225
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N205}
leucine-rich repeat
SITE: 228-252
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 277-303
MOTIF: leucine residue (SEVERAL)
cysteine residue {C281}
MODIFICATION: cysteine residue {C306}
N-glycosylation site {N282}
cysteine residue {C306}
MODIFICATION: cysteine residue {C281}
leucine-rich repeat
SITE: 307-330
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N309}
leucine-rich repeat
SITE: 332-350
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 351-372
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 373-398
MOTIF: leucine residue (SEVERAL)
cysteine residue {C390}
MODIFICATION: cysteine residue {C391}
cysteine residue {C391}
MODIFICATION: cysteine residue {C390}
leucine-rich repeat
SITE: 400-421
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 422-445
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 447-469
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 470-494
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 495-518
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N497}
leucine-rich repeat
SITE: 520-541
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N526}
leucine-rich repeat
SITE: 543-566
MOTIF: leucine residue (SEVERAL)
leucine-rich repeat
SITE: 568-592
MOTIF: leucine residue (SEVERAL)
N-glycosylation site {N575}
cysteine residue {C583}
MODIFICATION: cysteine residue {C609}
cysteine residue {C585}
MODIFICATION: cysteine residue {C627}
cysteine residue {C609}
MODIFICATION: cysteine residue {C583}
N-glycosylation site {N624}
cysteine residue {C627}
MODIFICATION: cysteine residue {C585}
N-glycosylation site {N630}
transmembrane domain {632-652}
TIR domain {672-818}
References
UniProt :accession O00206
Components
CD14; monocyte differentiation antigen CD14; myeloid cell-specific leucine-rich glycoprotein
lymphocyte antigen 96; Ly-96; ESOP-1; protein MD-2 (LY96, ESOP1 MD2)
Toll-like receptor 4; hToll; CD284 (TLR4)